Two sample MR report

Telomere_length against rfMRI connectivity (ICA25 edge 25)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0675482	0.1108598	0.5488535
Weighted median	23	-0.0327377	0.0620622	0.5978477
Inverse variance weighted	23	-0.0477121	0.0423727	0.2601610
Simple mode	23	0.0708203	0.1309950	0.5941922
Weighted mode	23	-0.1872719	0.0992548	0.0724572

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	25.90327	21	0.2101615
Inverse variance weighted	25.94988	22	0.2538401

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0012182	0.0062664	0.8477356

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008316	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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