Two sample MR report

Telomere_length against rfMRI connectivity (ICA25 edge 24)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1122996	0.1089426	0.3143544
Weighted median	23	0.0177736	0.0573307	0.7565469
Inverse variance weighted	23	0.0180250	0.0424685	0.6712500
Simple mode	23	-0.0516298	0.0921775	0.5810618
Weighted mode	23	0.0213438	0.0605130	0.7276589

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	25.01347	21	0.2465813
Inverse variance weighted	26.06627	22	0.2488476

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0057894	0.0061579	0.357831

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007963	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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