Two sample MR report

Telomere_length against rfMRI connectivity (ICA25 edge 23)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0539096	0.0998208	0.5948347
Weighted median	23	-0.0050550	0.0567540	0.9290281
Inverse variance weighted	23	0.0332951	0.0390158	0.3934513
Simple mode	23	0.0972316	0.1138062	0.4021130
Weighted mode	23	-0.0423600	0.0685089	0.5427178

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	17.35761	21	0.6892141
Inverse variance weighted	18.25842	22	0.6905612

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0053552	0.0056423	0.3533587

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0005754	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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