Two sample MR report

Telomere_length against rfMRI connectivity (ICA25 edge 22)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0104128	0.0998206	0.9179095
Weighted median	23	0.0158028	0.0583705	0.7865966
Inverse variance weighted	23	0.0648298	0.0390154	0.0965840
Simple mode	23	0.0095086	0.0970822	0.9228637
Weighted mode	23	0.0067330	0.0736215	0.9279595

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	19.86252	21	0.5299836
Inverse variance weighted	20.53315	22	0.5497272

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0046206	0.0056423	0.422028

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007059	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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