Two sample MR report

Telomere_length against rfMRI connectivity (ICA25 edge 210)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0402627	0.0998205	0.6907677
Weighted median	23	-0.0276912	0.0554399	0.6174399
Inverse variance weighted	23	-0.0394425	0.0390155	0.3120435
Simple mode	23	0.0147443	0.0896672	0.8708913
Weighted mode	23	-0.0089830	0.0770658	0.9082641

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	13.78308	21	0.8787351
Inverse variance weighted	13.78316	22	0.9089960

Test for directional horizontal pleiotropy

egger_intercept	se	pval
5.04e-05	0.0056424	0.9929617

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0004486	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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