Two sample MR report

Telomere_length against rfMRI connectivity (ICA25 edge 21)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0479974	0.0998205	0.6356040
Weighted median	23	0.0210679	0.0571097	0.7122011
Inverse variance weighted	23	0.0405501	0.0390155	0.2986491
Simple mode	23	0.0075530	0.0949090	0.9372895
Weighted mode	23	0.0127707	0.0656300	0.8475031

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	18.63175	21	0.6087502
Inverse variance weighted	18.63832	22	0.6675434

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0004573	0.0056423	0.9361662

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0005975	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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