Two sample MR report

Telomere_length against rfMRI connectivity (ICA25 edge 209)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0077366	0.1286759	0.9526248
Weighted median	23	-0.0041474	0.0564762	0.9414596
Inverse variance weighted	23	-0.0195569	0.0491492	0.6906972
Simple mode	23	0.0559878	0.0840007	0.5120115
Weighted mode	23	0.0105127	0.0587625	0.8596518

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	34.89574	21	0.0289879
Inverse variance weighted	34.91229	22	0.0395703

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0007259	0.0072733	0.9214496

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0010655	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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