Two sample MR report

Telomere_length against rfMRI connectivity (ICA25 edge 208)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0421126	0.0998208	0.6773984
Weighted median	23	-0.0077219	0.0545987	0.8875295
Inverse variance weighted	23	0.0382575	0.0390156	0.3268054
Simple mode	23	-0.0113286	0.0852477	0.8954885
Weighted mode	23	-0.0113286	0.0675836	0.8684112

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	18.52984	21	0.6152723
Inverse variance weighted	19.29499	22	0.6270492

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0049355	0.0056423	0.3916173

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006138	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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