Two sample MR report

Telomere_length against rfMRI connectivity (ICA25 edge 207)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1251524	0.0998203	0.2237013
Weighted median	23	-0.0379519	0.0570152	0.5056373
Inverse variance weighted	23	-0.0277639	0.0390157	0.4767067
Simple mode	23	0.0234252	0.0903511	0.7978390
Weighted mode	23	-0.0376663	0.0673854	0.5818286

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	17.50906	21	0.6798250
Inverse variance weighted	18.63257	22	0.6678943

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0059806	0.0056423	0.3012034

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.00058	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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