Two sample MR report

Telomere_length against rfMRI connectivity (ICA25 edge 206)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.2295924	0.1288847	0.0893206
Weighted median	23	0.0040941	0.0630414	0.9482197
Inverse variance weighted	23	-0.0168133	0.0540374	0.7556925
Simple mode	23	-0.0008933	0.1159696	0.9939238
Weighted mode	23	0.0436703	0.0704074	0.5414643

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	35.01050	21	0.0281603
Inverse variance weighted	42.20296	22	0.0059065

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0151317	0.0072851	0.0502572

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0012844	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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