Two sample MR report

Telomere_length against rfMRI connectivity (ICA25 edge 205)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0157307	0.0998208	0.8762859
Weighted median	23	-0.0562300	0.0540944	0.2985819
Inverse variance weighted	23	-0.0474117	0.0390157	0.2242921
Simple mode	23	-0.0814989	0.0877923	0.3633185
Weighted mode	23	-0.0589289	0.0639499	0.3667922

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	12.08863	21	0.9371942
Inverse variance weighted	12.56091	22	0.9446892

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0038776	0.0056424	0.4994608

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0004254	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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