Two sample MR report

Telomere_length against rfMRI connectivity (ICA25 edge 204)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0900551	0.0998208	0.3771992
Weighted median	23	0.0130064	0.0544357	0.8111590
Inverse variance weighted	23	-0.0064435	0.0390157	0.8688244
Simple mode	23	0.0408172	0.0829737	0.6276424
Weighted mode	23	0.0196105	0.0614398	0.7525994

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	14.93442	21	0.8262279
Inverse variance weighted	16.03748	22	0.8140212

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.005926	0.0056423	0.3055323

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0004868	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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