Two sample MR report

Telomere_length against rfMRI connectivity (ICA25 edge 203)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0764234	0.1115215	0.5006627
Weighted median	23	0.0266937	0.0591743	0.6519151
Inverse variance weighted	23	0.0235400	0.0435380	0.5887302
Simple mode	23	0.0173663	0.0947019	0.8561805
Weighted mode	23	0.0313486	0.0792633	0.6962834

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	26.21261	21	0.1984580
Inverse variance weighted	27.39635	22	0.1965581

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0061387	0.0063037	0.341227

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008412	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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