Two sample MR report

Telomere_length against rfMRI connectivity (ICA25 edge 202)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0096640	0.0998207	0.9237924
Weighted median	23	-0.0442683	0.0535324	0.4082689
Inverse variance weighted	23	0.0020075	0.0390156	0.9589644
Simple mode	23	-0.0771625	0.0923978	0.4126321
Weighted mode	23	-0.0502191	0.0629225	0.4333381

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	17.88917	21	0.6560067
Inverse variance weighted	17.90531	22	0.7115878

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0007167	0.0056424	0.9001255

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0005426	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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