Two sample MR report

Telomere_length against rfMRI connectivity (ICA25 edge 201)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1950831	0.0998190	0.0641028
Weighted median	23	-0.0924592	0.0566221	0.1024865
Inverse variance weighted	23	-0.0882364	0.0390151	0.0237225
Simple mode	23	-0.0426213	0.0990955	0.6713047
Weighted mode	23	-0.1385226	0.0705452	0.0623386

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	12.24518	21	0.9327611
Inverse variance weighted	13.59754	22	0.9151457

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0065615	0.0056423	0.2579097

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.000567	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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