Two sample MR report

Telomere_length against rfMRI connectivity (ICA25 edge 200)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1353657	0.0998197	0.1894699
Weighted median	23	-0.0553673	0.0555577	0.3189713
Inverse variance weighted	23	-0.0561460	0.0390153	0.1501284
Simple mode	23	-0.0934116	0.0987294	0.3543551
Weighted mode	23	-0.0760901	0.0691435	0.2830244

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	19.65506	21	0.5431946
Inverse variance weighted	20.39847	22	0.5581295

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0048649	0.0056423	0.3983077

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006809	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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