Two sample MR report

Telomere_length against rfMRI connectivity (ICA25 edge 20)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0412294	0.1123673	0.7173530
Weighted median	23	0.0469541	0.0592974	0.4284533
Inverse variance weighted	23	-0.0048562	0.0430361	0.9101575
Simple mode	23	0.0392112	0.0943647	0.6817802
Weighted mode	23	0.0068338	0.0684428	0.9213700

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	26.61110	21	0.1840995
Inverse variance weighted	26.76782	22	0.2201780

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0022337	0.0063515	0.7285867

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008116	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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