Two sample MR report

Telomere_length against rfMRI connectivity (ICA25 edge 2)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0091775	0.1084179	0.9333418
Weighted median	23	-0.0162830	0.0591733	0.7831818
Inverse variance weighted	23	-0.0036150	0.0414048	0.9304269
Simple mode	23	-0.0081351	0.0997439	0.9357340
Weighted mode	23	-0.0330677	0.0776136	0.6742072

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	24.77341	21	0.2571113
Inverse variance weighted	24.77707	22	0.3078538

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0003416	0.0061283	0.9560752

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007511	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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