Two sample MR report

Telomere_length against rfMRI connectivity (ICA25 edge 199)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0825365	0.1009156	0.4226110
Weighted median	23	-0.0352603	0.0590511	0.5504306
Inverse variance weighted	23	0.0126839	0.0394894	0.7480598
Simple mode	23	-0.0304265	0.0933075	0.7474388
Weighted mode	23	-0.0543422	0.0773857	0.4899024

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	21.46398	21	0.4309404
Inverse variance weighted	22.53805	22	0.4281936

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0058475	0.0057043	0.3169742

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006861	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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