Two sample MR report

Telomere_length against rfMRI connectivity (ICA25 edge 198)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0265842	0.0998210	0.7925913
Weighted median	23	0.0535309	0.0541832	0.3231711
Inverse variance weighted	23	0.0438784	0.0390157	0.2607445
Simple mode	23	0.0387575	0.0843541	0.6504103
Weighted mode	23	0.0415772	0.0607652	0.5009768

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	18.52602	21	0.6155164
Inverse variance weighted	18.56145	22	0.6722296

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.001062	0.0056423	0.8525072

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006008	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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