Two sample MR report

Telomere_length against rfMRI connectivity (ICA25 edge 197)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0142521	0.0998204	0.8878271
Weighted median	23	0.0604851	0.0539609	0.2623279
Inverse variance weighted	23	-0.0063846	0.0390155	0.8700122
Simple mode	23	0.1137060	0.0978178	0.2575176
Weighted mode	23	0.0732310	0.0668533	0.2851898

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	17.73381	21	0.6657813
Inverse variance weighted	17.74115	22	0.7212207

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0004831	0.0056423	0.9325733

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0005384	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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