Two sample MR report

Telomere_length against rfMRI connectivity (ICA25 edge 196)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0397585	0.0998204	0.6944296
Weighted median	23	-0.0829352	0.0530981	0.1183061
Inverse variance weighted	23	-0.0650879	0.0390156	0.0952651
Simple mode	23	-0.0477544	0.0929128	0.6123970
Weighted mode	23	-0.0606742	0.0643410	0.3559176

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	20.50101	21	0.4897552
Inverse variance weighted	20.57701	22	0.5469942

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0015555	0.0056423	0.7854885

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007079	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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