Two sample MR report

Telomere_length against rfMRI connectivity (ICA25 edge 195)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0784899	0.1020551	0.4504018
Weighted median	23	0.0002837	0.0602874	0.9962456
Inverse variance weighted	23	0.0643122	0.0390151	0.0992719
Simple mode	23	0.0053104	0.1076382	0.9610967
Weighted mode	23	-0.0106127	0.0920215	0.9092311

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	21.95185	21	0.4022893
Inverse variance weighted	21.97566	22	0.4613424

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0008707	0.0057687	0.8814724

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007482	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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