Two sample MR report

Telomere_length against rfMRI connectivity (ICA25 edge 194)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1099333	0.1299667	0.4071676
Weighted median	23	0.0389835	0.0602322	0.5174893
Inverse variance weighted	23	0.0532109	0.0498953	0.2862196
Simple mode	23	0.0360192	0.0976230	0.7156830
Weighted mode	23	0.0274513	0.0701109	0.6991636

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	35.59996	21	0.0242372
Inverse variance weighted	35.98108	22	0.0305083

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0034833	0.0073464	0.6402815

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0011466	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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