Two sample MR report

Telomere_length against rfMRI connectivity (ICA25 edge 193)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0387093	0.1019964	0.7081154
Weighted median	23	0.0526315	0.0563852	0.3505988
Inverse variance weighted	23	0.0189350	0.0390155	0.6274491
Simple mode	23	0.0432398	0.0993491	0.6676345
Weighted mode	23	0.0461957	0.0657036	0.4893726

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	21.92542	21	0.4038184
Inverse variance weighted	21.97174	22	0.4615765

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0012143	0.0057653	0.8352087

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006729	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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