Two sample MR report

Telomere_length against rfMRI connectivity (ICA25 edge 192)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0025761	0.1049619	0.9806509
Weighted median	23	-0.0594013	0.0569486	0.2969167
Inverse variance weighted	23	-0.0484061	0.0403467	0.2302352
Simple mode	23	0.0785755	0.1004323	0.4423355
Weighted mode	23	-0.0458478	0.0646551	0.4857013

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	23.21902	21	0.3324125
Inverse variance weighted	23.52692	22	0.3725065

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0031308	0.005933	0.6032402

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007595	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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