Two sample MR report

Telomere_length against rfMRI connectivity (ICA25 edge 191)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0979585	0.1029534	0.3521821
Weighted median	23	-0.0094020	0.0572740	0.8696061
Inverse variance weighted	23	0.0455030	0.0414048	0.2717771
Simple mode	23	0.1135996	0.1172954	0.3433267
Weighted mode	23	-0.0332036	0.0694108	0.6371114

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	22.33907	21	0.3802018
Inverse variance weighted	24.77707	22	0.3078538

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.00881	0.0058194	0.14496

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.000792	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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