Two sample MR report

Telomere_length against rfMRI connectivity (ICA25 edge 190)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1069827	0.0998206	0.2959956
Weighted median	23	-0.0037254	0.0536448	0.9446350
Inverse variance weighted	23	-0.0311415	0.0390158	0.4247676
Simple mode	23	-0.0832150	0.0909081	0.3699199
Weighted mode	23	0.0066945	0.0610696	0.9137038

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	17.59749	21	0.6743144
Inverse variance weighted	19.85743	22	0.5919572

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0084822	0.0056423	0.1476492

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.000621	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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