Two sample MR report

Telomere_length against rfMRI connectivity (ICA25 edge 19)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0567509	0.0998197	0.5757020
Weighted median	23	0.0518087	0.0614224	0.3989589
Inverse variance weighted	23	0.0433619	0.0390153	0.2663930
Simple mode	23	0.1404761	0.1050480	0.1948020
Weighted mode	23	0.1019312	0.0988388	0.3136113

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	18.05707	21	0.6453896
Inverse variance weighted	19.24433	22	0.6301962

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0061479	0.0056423	0.2882294

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006206	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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