Two sample MR report

Telomere_length against rfMRI connectivity (ICA25 edge 189)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0807645	0.1225266	0.5169574
Weighted median	23	-0.0539592	0.0561000	0.3361294
Inverse variance weighted	23	-0.0415201	0.0469242	0.3762461
Simple mode	23	-0.2064283	0.0941332	0.0391765
Weighted mode	23	-0.0762757	0.0597697	0.2152076

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	31.64085	21	0.063634
Inverse variance weighted	31.82329	22	0.080459

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.00241	0.0069258	0.7313238

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009987	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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