Two sample MR report

Telomere_length against rfMRI connectivity (ICA25 edge 188)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0862313	0.1034120	0.4137433
Weighted median	23	0.0525303	0.0569459	0.3562890
Inverse variance weighted	23	-0.0007682	0.0402678	0.9847797
Simple mode	23	-0.0459721	0.1093719	0.6783228
Weighted mode	23	0.0570275	0.0771122	0.4673983

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	22.53831	21	0.3690793
Inverse variance weighted	23.43490	22	0.3775311

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0053426	0.0058454	0.3710932

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007101	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8