Two sample MR report

Telomere_length against rfMRI connectivity (ICA25 edge 187)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0944916	0.0998210	0.3546032
Weighted median	23	0.0391277	0.0538372	0.4673621
Inverse variance weighted	23	0.0587511	0.0390158	0.1321114
Simple mode	23	0.0738327	0.0884733	0.4129587
Weighted mode	23	0.0030758	0.0601532	0.9596808

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	18.67568	21	0.6059361
Inverse variance weighted	21.45741	22	0.4926445

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0094106	0.0056424	0.1101897

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007189	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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