Two sample MR report

Telomere_length against rfMRI connectivity (ICA25 edge 186)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0680184	0.0998205	0.5030597
Weighted median	23	-0.0330681	0.0558559	0.5538343
Inverse variance weighted	23	-0.0022386	0.0390156	0.9542452
Simple mode	23	-0.0344299	0.0927107	0.7139152
Weighted mode	23	-0.0463723	0.0666980	0.4941725

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	19.36375	21	0.5618183
Inverse variance weighted	19.94846	22	0.5862641

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0043145	0.0056423	0.4529808

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006046	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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