Two sample MR report

Telomere_length against rfMRI connectivity (ICA25 edge 184)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0128574	0.0998201	0.8987369
Weighted median	23	0.0402781	0.0526863	0.4445751
Inverse variance weighted	23	0.0778104	0.0390155	0.0461143
Simple mode	23	0.0744746	0.0939431	0.4363824
Weighted mode	23	0.0155546	0.0597515	0.7970365

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	19.7403	21	0.5377600
Inverse variance weighted	20.7141	22	0.5384621

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0055679	0.0056423	0.3349686

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007482	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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