Two sample MR report

Telomere_length against rfMRI connectivity (ICA25 edge 183)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0500498	0.0998213	0.6213091
Weighted median	23	0.0272467	0.0531036	0.6078917
Inverse variance weighted	23	0.0422377	0.0390159	0.2789959
Simple mode	23	0.0213967	0.0830835	0.7991616
Weighted mode	23	0.0348572	0.0616584	0.5775713

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	12.00581	21	0.9394608
Inverse variance weighted	12.01304	22	0.9571091

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0004797	0.0056424	0.9330471

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0003995	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8