Two sample MR report

Telomere_length against rfMRI connectivity (ICA25 edge 182)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1532216	0.1078730	0.1701720
Weighted median	23	-0.0389998	0.0643210	0.5442949
Inverse variance weighted	23	-0.0359609	0.0446124	0.4202001
Simple mode	23	-0.1466006	0.1144299	0.2134855
Weighted mode	23	-0.1190264	0.0883458	0.1916040

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	24.52551	21	0.2682989
Inverse variance weighted	28.76520	22	0.1516873

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0116178	0.0060975	0.0705228

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008974	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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