Two sample MR report

Telomere_length against rfMRI connectivity (ICA25 edge 181)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.2208961	0.0998186	0.0381078
Weighted median	23	0.0187295	0.0591520	0.7515216
Inverse variance weighted	23	0.0313210	0.0395059	0.4278842
Simple mode	23	-0.0481144	0.1149424	0.6795700
Weighted mode	23	0.0863105	0.0726013	0.2471815

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	18.29971	21	0.6299669
Inverse variance weighted	22.55705	22	0.4270905

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0116419	0.0056423	0.0516604

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007031	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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