Two sample MR report

Telomere_length against rfMRI connectivity (ICA25 edge 180)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1016774	0.1201292	0.4068718
Weighted median	23	-0.1220410	0.0624371	0.0506277
Inverse variance weighted	23	-0.0936716	0.0458802	0.0411857
Simple mode	23	-0.1851082	0.1396423	0.1985774
Weighted mode	23	-0.2120104	0.1646092	0.2111425

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	30.41677	21	0.0839275
Inverse variance weighted	30.42436	22	0.1085098

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0004916	0.0067904	0.9429667

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0010966	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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