Two sample MR report

Telomere_length against rfMRI connectivity (ICA25 edge 18)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0889918	0.1110039	0.4317054
Weighted median	23	-0.0706011	0.0589444	0.2310119
Inverse variance weighted	23	-0.0413558	0.0426081	0.3317426
Simple mode	23	-0.0445294	0.1126742	0.6964974
Weighted mode	23	-0.0870700	0.0730162	0.2457787

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	25.9697	21	0.2076069
Inverse variance weighted	26.2385	22	0.2415829

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0029253	0.0062745	0.645854

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008291	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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