Two sample MR report

Telomere_length against rfMRI connectivity (ICA25 edge 179)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1424513	0.1039811	0.1851657
Weighted median	23	0.0399300	0.0538850	0.4586800
Inverse variance weighted	23	-0.0005894	0.0417658	0.9887397
Simple mode	23	0.0342447	0.0903791	0.7083942
Weighted mode	23	0.0535223	0.0591853	0.3756237

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	22.78722	21	0.3554275
Inverse variance weighted	25.21094	22	0.2870941

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0087841	0.0058775	0.1499125

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007639	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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