Two sample MR report

Telomere_length against rfMRI connectivity (ICA25 edge 178)

Date: 22 April, 2022

Results from two sample MR:

method nsnp b se pval
MR Egger 23 0.0919751 0.1018744 0.3768570
Weighted median 23 -0.0796930 0.0588438 0.1756363
Inverse variance weighted 23 -0.0058361 0.0398983 0.8837040
Simple mode 23 -0.0926864 0.1092675 0.4054328
Weighted mode 23 -0.0926864 0.1049659 0.3867762

Heterogeneity tests

method Q Q_df Q_pval
MR Egger 21.87377 21 0.4068153
Inverse variance weighted 23.00708 22 0.4013298

Test for directional horizontal pleiotropy

egger_intercept se pval
-0.0060066 0.0057585 0.3087649

Test that the exposure is upstream of the outcome

snp_r2.exposure snp_r2.outcome correct_causal_direction steiger_pval
0.0357937 0.0006979 TRUE 0

Note - R2 values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8