Two sample MR report

Telomere_length against rfMRI connectivity (ICA25 edge 177)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0721875	0.1235758	0.5653385
Weighted median	23	-0.0110155	0.0570167	0.8468040
Inverse variance weighted	23	-0.0223086	0.0479590	0.6418178
Simple mode	23	-0.1017632	0.1020494	0.3295118
Weighted mode	23	-0.0022513	0.0641541	0.9723224

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	32.18466	21	0.0560768
Inverse variance weighted	33.24243	22	0.0585441

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.005803	0.0069851	0.415451

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0010172	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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