Two sample MR report

Telomere_length against rfMRI connectivity (ICA25 edge 176)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0761967	0.1055368	0.4782631
Weighted median	23	0.0321018	0.0594572	0.5892559
Inverse variance weighted	23	-0.0241046	0.0413116	0.5595691
Simple mode	23	0.0756007	0.1105216	0.5010951
Weighted mode	23	0.0652639	0.0685861	0.3516578

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	23.47408	21	0.3192314
Inverse variance weighted	24.66580	22	0.3133222

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0061595	0.0059655	0.313571

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.000759	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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