Two sample MR report

Telomere_length against rfMRI connectivity (ICA25 edge 175)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1028710	0.1044207	0.3357614
Weighted median	23	0.1294858	0.0618735	0.0363715
Inverse variance weighted	23	0.0830859	0.0399159	0.0373861
Simple mode	23	-0.0682135	0.1141465	0.5562111
Weighted mode	23	0.1345927	0.0831897	0.1199329

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	22.98143	21	0.3449695
Inverse variance weighted	23.02780	22	0.4001613

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.001215	0.0059024	0.8388905

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008352	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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