Two sample MR report

Telomere_length against rfMRI connectivity (ICA25 edge 174)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1612541	0.1023432	0.1300591
Weighted median	23	0.0500041	0.0563121	0.3745502
Inverse variance weighted	23	0.0216144	0.0410756	0.5987411
Simple mode	23	0.0327725	0.0917608	0.7243811
Weighted mode	23	0.0523126	0.0619164	0.4072672

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	22.0748	21	0.3952104
Inverse variance weighted	24.3846	22	0.3273970

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0085752	0.0057849	0.1531009

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007482	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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