Two sample MR report

Telomere_length against rfMRI connectivity (ICA25 edge 173)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0085694	0.0998207	0.9324006
Weighted median	23	0.0617115	0.0548153	0.2602470
Inverse variance weighted	23	0.0293384	0.0390157	0.4520739
Simple mode	23	0.0087271	0.0865472	0.9205942
Weighted mode	23	0.0453954	0.0598677	0.4563411

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	19.41337	21	0.5586411
Inverse variance weighted	19.58359	22	0.6090691

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0023279	0.0056423	0.684097

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006106	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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