Two sample MR report

Telomere_length against rfMRI connectivity (ICA25 edge 172)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1358858	0.1039375	0.2052178
Weighted median	23	-0.0044062	0.0564534	0.9377880
Inverse variance weighted	23	-0.0684766	0.0437912	0.1178863
Simple mode	23	0.0262776	0.0970257	0.7890454
Weighted mode	23	0.0206765	0.0637274	0.7486603

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	22.76808	21	0.3564677
Inverse variance weighted	27.71532	22	0.1853086

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0125499	0.005875	0.0446017

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009332	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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