Two sample MR report

Telomere_length against rfMRI connectivity (ICA25 edge 171)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1145575	0.0998212	0.2640289
Weighted median	23	0.0503225	0.0545617	0.3563696
Inverse variance weighted	23	0.0501921	0.0390157	0.1982838
Simple mode	23	0.0485233	0.0927091	0.6059328
Weighted mode	23	0.0457787	0.0606318	0.4582393

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	16.22147	21	0.7570814
Inverse variance weighted	16.71221	22	0.7790386

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0039527	0.0056424	0.4912832

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0005566	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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