Two sample MR report

Telomere_length against rfMRI connectivity (ICA25 edge 170)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.2414254	0.1079161	0.0362497
Weighted median	23	0.0266835	0.0567909	0.6384587
Inverse variance weighted	23	0.0212923	0.0457760	0.6418299
Simple mode	23	0.0680303	0.0983866	0.4965096
Weighted mode	23	0.0680303	0.0641125	0.3001513

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	24.54456	21	0.2674278
Inverse variance weighted	30.28483	22	0.1117043

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0135183	0.0060999	0.0378593

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009267	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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