Two sample MR report

Telomere_length against rfMRI connectivity (ICA25 edge 17)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0374538	0.1148584	0.7475857
Weighted median	23	-0.0898913	0.0579195	0.1206609
Inverse variance weighted	23	-0.0337259	0.0443322	0.4468042
Simple mode	23	-0.0951470	0.0897096	0.3003726
Weighted mode	23	-0.1012323	0.0707548	0.1665538

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	27.80472	21	0.1457771
Inverse variance weighted	28.40491	22	0.1626474

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0043712	0.0064924	0.5081144

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008834	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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